Efficient One-pot Syntheses of 3-Amino-2-pyrones and 3-Amino-5,6-dihydro-2-pyridones
from β,γ-Unsaturated α-Iminoesters: Application to the Synthesis of A Tricyclic
Pyranoindole, Kenta Nakahama, Misato Suzuki, Mami Ozako, Isao Mizota, Makoto
Shimizu, Asian J. Org. Chem. 2018
Umpolung Reaction of α-Imino Thioesters and the Subsequent C-C Bond Formation
with the Unexpected Alkylthio Rearrangement, Isao Mizota, Chihiro Ueda,
Yun Tesong, Yusuke Tsujimoto, Makoto Shimizu, Org. Lett. 2018
Synthesis of 1,2-Diamino Acid Derivatives Utilizing Diastereoselective
-Alkylation/Homo- and Cross-addition Reaction of α-Aldimino Thioesters,
Isao Mizota, Yuji Nakajima, Asako Higashino, Makoto Shimizu, Arab. J. Sci. Eng. 2017
Development of Novel Reaction Utilizing Iodination Ability of TiI4, Iwao
Hachiya, Isao Mizota, Makoto Shimizu, J. Synth. Org. Chem. Jpn. 2017
Synthesis of δ-Lactone and Amino Acid Frameworks Utilizing the Umpoled
Reactivity of β,γ-Alkenyl α-Iminoester
Mami Kawanishi, Isao Mizota, Kana Aratake, Hirotaka Tanaka, Kenta Nakahama,
Makoto Shimizu, Bull. Chem. Soc. Jpn
Synthesis of Multi-Substituted 1,4-Benzoxazine Using an Umpolung Reaction
with 2-Oxo-1,4-benzoxazine-3-carboxylates, Takanori Tanaka, Isao Mizota,
Kazuto Umezu, Akinori Ito, Makoto Shimizu, Heterocycles 2017
, in press
Titanium tetraiodide-mediated diastereoselective iodo-aldol and Mannich
reactions of γ-alkoxy-α,β-alkynyl ketone derivatives, Kai Yashiro, Shingo
Ito, Shota Kayaki, Keito Sakata, Isao Mizota, Iwao Hachiya, Makoto Shimizu,
Exploration into a New Dicarboxylic Acid Derived from Ricinoleic Acid for
the Aluminum Electrolytic Capacitors of High Performance, Isao Mizota,
Satoshi Umeshima, Sei Matsunaga, Rinpei Isomura, Kenta Nakahama, Makoto
Shimizu, Yorozu Yokomori, Tokihiro Umemura, Noburo Kuroki, Junichi Kiyosawa,
Hiroyuki Tanaka, Bull. Chem. Soc. Jpn
Formal Total Synthesis of Artocarpin, Isao Mizota, Kana Taniguchi, Makoto
Shimizu, Heterocycles 2016
, (1) 310-322.
Umpolung Reactions of α-Imino Esters: Useful Methods for the Preparation
of α-Amino Acid Frameworks, Isao Mizota, Makoto Shimizu, Chem. Rec
Synthesis of (±)-muscopyridine analogue using ring-expansion reaction of
cyclic β-keto ester via conjugate addition to alkynyl imine, Iwao Hachiya,
Naoki Kugisaki, Ryosuke Agata, Hisae Matsumoto, Yoshiyasu Yamada, Makoto
Highly efficient sequential N,N,C-trialkylation of α-N
-acyloxyimino esters, Isao Mizota, Tatsuya Maeda, Makoto Shimizu, Tetrahedron 2015
Synthesis of Multisubstituted Dihydroquinoxaline Derivatives by Tandem
-Alkylation and Addition Reactions of 3-Oxoquinoxaline-2-carboxylates,
Satoru Miyamaru, Kazuto Umezu, Akinori Ito, and Makoto Shimizu, Eur. J.
Org. Chem. 2015
Nucleophilic Addition Reaction to the Iminium Salts Generated from Pipecolic
Acid Derivatives and Application to the Synthesis of Bicyclic Compounds,
Makoto Shimizu, Atsuhiro Yato and Takato Kawamura, Asian J. Org. Chem
2-Aryl-4-quinolone Synthesis Using the Thermal Rearrangement of Iminocyclobutenones，Iwao
Hachiya, Keiichi Yokoyama, Akinori Ito, and Makoto Shimizu，Heterocycles
, 90, (1), 97-103.
-Alkylation of α-Iminophosphonates and application to Horner-Wadsworth-Emmons Reaction, Makoto Shimizu, Masasato Tateishi, and Isao Mizota, Chem. Lett.
, 43, (11), 1752-1754.
Chiral β-Lactam Synthesis through the Enantioselective Reduction of Iminocyclobutenones
and Thermal Rearrangement of Aminocyclobutenones, Iwao Hachiya, Akinori
Ito, and Makoto Shimizu, Asian J. Org. Chem.
, 3, (5), 614-618.
Titanium Tetraiodide-Mediated Organic Reactions, Tsuyoshi Haneishi, Iwao
Hachiya, and Makoto Shimizu, Arabian J. Sci. Eng.
, 39,(9), 6599-6616.
Integrated reactions based on the sequential addition to α-imino esters,
Kaichiro Koyama, Isao Mizota, and Makoto Shimizu, Pure Appl. Chem.
, 86, (5), 755-764.
Chemoselective reductions and iodinations using titanium tetraiodide, Iwao
Hachiya and Makoto Shimizu，Tetrahedron Lett.
, 55, (17), 2781-2788.
-Alkylation/Vinylogous Aldol Reaction of β,γ-Alkenyl α-Iminoester, Hirotaka
Tanaka, Isao Mizota, and Makoto Shimizu, Org. Lett.
, 16, (8) 2276-2279.
Two-Step Synthesis of 3,4-Ethylenedioxythiophene (EDOT) from 2,3-Butanedione,
Iwao Hachiya, Toshihiro Yamamoto, Tatsuhiko Inagaki, Tomohiro Matsumoto,
Atsushi Takahashi, Isao Mizota, and Makoto Shimizu, Heterocycles
, 88, (1), 607-612.
Diastereoselective Iodo Aldol Reaction of g-Alkoxy a,b-Alkynyl Ketone Derivatives
Promoted by Titnium Tetraiodide，Iwao Hachiya, Shingo Ito, Shota Kayaki,
and Makoto Shimizu, Asian J. Org. Chem.
, 2, (11), 931-934.
Regioselective Tandem N
-Acylation of β,γ-Alkynyl α-Imino Esters, Isao Mizota, Yuri Matsuda, Satoshi
Kamimura, Hirotaka Tanaka, and Makoto Shimizu, Org. Lett.
, 15, (16), 4206-4209.
Synthesis of Azulene Derivatives Having an Azathiacrown Ether Moiety and
Their Selective Color Reaction toward Silver Ion, Shigeharu Wakabayashi,
Miyuki Uchida, Rika Tanaka, and Makoto Shimizu, Asian J. Org. Chem.
, 2, (9), 786-791.
-Alkylation-Addition Reaction of α-Imino Esters and Application to a New
Flow System, Takanori Sano, Isao Mizota, and Makoto Shimizu, Chem. Lett.
, 42, (9) 995-997.
Highly Diastereoselective Tandem N
-Alkylation-Mannich Reaction of α-Imino Esters, M. Shimizu, D. Kurita,
and I. Mizota, Asian J. Org. Chem.
, 2, (3) 208-211.
A new single-ion polymer electrolyte based on polyvinyl alcohol for lithium
ion batteries, Y. S. Zhu, X. J. Wang, Y. Y. Hou, X. W. Gao, L. L. Liu,
Y. P. Wu, and M. Shimizu, Electrochimica Acta
, 87, (1) 113–118.
Synthesis of Indolin-3-ones and Tetrahydro-4-quinolones Using α-Imino Esters,
M. Shimizu, Y. Takao, H. Katsurayama, and I. Mizota, Asian J. Org. Chem.
, 2, (2) 130-134.
Synthesis of a-Amino Ketones and O-Alkyloximes by Titanium Tetrahalide
Promoted Ring-opening Reaction of 2-Mono-substitued Azetidine-3-ones and
Their O-Alkyloximes, S. Ariga, S. Hata, D. Fukuda, T. Nishi, I. Hachiya,
and M. Shimizu, Heterocycles
, 86, (2), 1187-1210.
Synthesis of a-Dialkylamino Esters Using Tandem N,N-Dialkylation of a-Sulfoximino
Ester, S. Hata, T. Maeda, and M. Shimizu, Bull. Chem. Soc. Jpn.
, 85, (11) 1203-1205.
Sulfur-Containing Pyridylazulenes: Synthesis and Chromogenic Behaviors
for Heavy Metal Ions, S. Wakabayashi, E. Matsumoto, M. Nishiguchi, R. Yamaoka,
M. Ishiura, M. Tsuji, and M. Shimizu, Heterocycles
, 85, (9), 2251-2258.
Integrated Reactions Using Addition to Conjugated Imines and Iminium Salts,
Takafumi Nishi, Isao Mizota, and Makoto Shimizu, Pure Appl. Chem.
, 84, (12) 2609-2617.
Synthesis of Nitrogen-containing Heterocycles Using Conjugate Addition
Reactions of Nucleophiles to a,b-Unsaturated Imines, Iwao Hachiya, Isao
Mizota, and Makoto Shimizu, Heterocycles
, 85, (5), 993-1016.
Synthesis of γ,δ-Unsaturated Quaternary α-Alkylamino Acids Using Umpolung
Reaction and Claisen Rearrangement, Isao Mizota, Katsuki Tanaka, and Makoto
Shimizu, Tetrahedron Lett.
, 53, (14), 1847-1850.
Regioselctive Ring-opening Reaction of 2-Mono-substituted Azetidin-3-ones
Promoted by the Combines Use of Titanium Tetraiodide and Its Chloro or
Bromo Counterpart, Shingo Hata, Daisuke Fukuda, Iwao Hachiya, and Makoto
, 84, (1), 301-307.
Synthesis of a,a-Disubstituted a-Amino Esters: Nucleophilic Addition to
Iminium Salts Generated from Amino Ketene Silyl Acetals, Shingo Hata, Hiroshi
Koyama, and Makoto Shimizu, J. Org. Chem.
, 76, (23), 9670-9677.
Reductive Aminopropylation of Ketene Silyl (Thio)acetals Leading to the
Synthesis of δ-Amino Esters, Isao Mizota, Shun Agatani, Iwao Hachiya, Makoto
Shimizu, Tetrahedron Lett.
, 52, (41) 5388-5391.
Double Nucleophilic Addition Reaction to Acrolein with Ketene Silyl Acetals
and Allylborolanes Catalyzed by Proline, Makoto Shimizu, Mami Kawanishi,
Akinori Itoh, Isao Mizota, and Iwao Hachiya, Chem. Lett.
, 40, (8) 862-863.
Research Progress of Gel Polymer Electrolytes for Lithium Ion Batteries,
Peng Zhang, Linlin Li, Dannong He, Yuping Wu, and Makoto Shimizu, Acta Polymerica Sinica
, (2) 125-131.
Titanium Tetraiodide Promoted Reductive Enolate Formation of a- Tosyloxy
Ketone Derivatives and Aldol Reaction with Aldehydes, Iwao Hachiya, Takao
Inagaki, Yasuhisa Ishihara, and Makoto Shimizu, Bull. Chem. Soc. Jpn.
, 84, (4) 419-421.
Efficient Mannich Reaction Using Iminium Salts Generated from Glycine Derivatives,
Makoto Shimizu, Toshiki Kusunoki, Mari Yoshida, Koichi Kondo, and Isao
Mizota, Chem. Lett.
, 40, (4) 351-353.
Titanium Tetraiodide Promoted Tandem Prins Reaction of Alkynes with Acetals:
Synthesis of (Z,Z)-1,5-Diiodo-1,3,5-triarylpenta-1,4-dienes, Makoto Shimizu,
Kanako Okura, Takuya Arai, and Iwao Hachiya, Chem. Lett.
, 39, (10) 1052-1054.
Use of N-Allylidene-1,1-diphenylethanamine as a Latent Acrolein Synthon
in the Double Nucleophilic Addition Reaction of Ketene Silyl (Thio)acetals
and Allylborolanes Makoto Shimizu, Mami Kawanishi, Isao Mizota, and Iwao
Hachiya, Org. Lett.
, 12, (16), 3571-3573.
Synthesis of 3,4-Ethylenedioxythiophene (EDOT) from (Z)-But-2-ene-1,4-diol
or But-2-yne-1,4-diol, Iwao Hachiya, Tomohiro Matsumoto, Tatsuhiko Inagaki,
Atsushi Takahashi, and Makoto Shimizu, Heterocycles
, 82, (1), 449-460.
A New Method for the Synthesis of Multi-substituted Pyrroles of Biological
Interest by Double Nucleophilic Addition to a,b-Unsaturated Imines, Atsushi
Takahashi, Shiho Kawai, Iwao Hachiya, and Makoto Shimizu, Eur. J. Org. Chem.
, (1) 191-200.
Reductive Aldol and Mannich-Type Reactions of Azetidin-3-ones Promoted
by Titanium Tetraiodide, Shingo Hata, Daisuke Fukuda, Iwao Hachiya, and
Makoto Shimizu, Chem. Asian J.
, 5, (1), 473-477.
Facile Synthesis and Ring-Opening of 4-(Tributylstannyl)pyrrolidine-2-carboxylates,
Makoto Shimizu, Hiromi Ando, Hitoshi Shibuya, and Iwao Hachiya, Heterocycles
, 80, (2), 773-778.