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Efficient One-pot Syntheses of 3-Amino-2-pyrones and 3-Amino-5,6-dihydro-2-pyridones from β,γ-Unsaturated α-Iminoesters: Application to the Synthesis of A Tricyclic Pyranoindole, Kenta Nakahama, Misato Suzuki, Mami Ozako, Isao Mizota, Makoto Shimizu, Asian J. Org. Chem. 2018, 7, 910-913.

Umpolung Reaction of α-Imino Thioesters and the Subsequent C-C Bond Formation with the Unexpected Alkylthio Rearrangement, Isao Mizota, Chihiro Ueda, Yun Tesong, Yusuke Tsujimoto, Makoto Shimizu, Org. Lett. 2018, 20, 2291-2296.

Synthesis of 1,2-Diamino Acid Derivatives Utilizing Diastereoselective Tandem N-Alkylation/Homo- and Cross-addition Reaction of α-Aldimino Thioesters, Isao Mizota, Yuji Nakajima, Asako Higashino, Makoto Shimizu, Arab. J. Sci. Eng. 2017, 42, 4249-4261.

Development of Novel Reaction Utilizing Iodination Ability of TiI4, Iwao Hachiya, Isao Mizota, Makoto Shimizu, J. Synth. Org. Chem. Jpn. 2017, 75, 1226-1237.

Synthesis of δ-Lactone and Amino Acid Frameworks Utilizing the Umpoled Reactivity of β,γ-Alkenyl α-Iminoester
Mami Kawanishi, Isao Mizota, Kana Aratake, Hirotaka Tanaka, Kenta Nakahama, Makoto Shimizu, Bull. Chem. Soc. Jpn. 2017, 90, 395-403.

Synthesis of Multi-Substituted 1,4-Benzoxazine Using an Umpolung Reaction with 2-Oxo-1,4-benzoxazine-3-carboxylates, Takanori Tanaka, Isao Mizota, Kazuto Umezu, Akinori Ito, Makoto Shimizu, Heterocycles 2017, in press.

Titanium tetraiodide-mediated diastereoselective iodo-aldol and Mannich reactions of γ-alkoxy-α,β-alkynyl ketone derivatives, Kai Yashiro, Shingo Ito, Shota Kayaki, Keito Sakata, Isao Mizota, Iwao Hachiya, Makoto Shimizu, Tetrahedron 2016, 72, 6875-6885.

Exploration into a New Dicarboxylic Acid Derived from Ricinoleic Acid for the Aluminum Electrolytic Capacitors of High Performance, Isao Mizota, Satoshi Umeshima, Sei Matsunaga, Rinpei Isomura, Kenta Nakahama, Makoto Shimizu, Yorozu Yokomori, Tokihiro Umemura, Noburo Kuroki, Junichi Kiyosawa, Hiroyuki Tanaka, Bull. Chem. Soc. Jpn. 2016, 89, 1368-1374.

Formal Total Synthesis of Artocarpin, Isao Mizota, Kana Taniguchi, Makoto Shimizu, Heterocycles 2016, 93, (1) 310-322.

Umpolung Reactions of α-Imino Esters: Useful Methods for the Preparation of α-Amino Acid Frameworks, Isao Mizota, Makoto Shimizu, Chem. Rec. 2016, 15, 688-702.

Synthesis of (±)-muscopyridine analogue using ring-expansion reaction of cyclic β-keto ester via conjugate addition to alkynyl imine, Iwao Hachiya, Naoki Kugisaki, Ryosuke Agata, Hisae Matsumoto, Yoshiyasu Yamada, Makoto Shimizu, Tetrahedron, 2015, 71, 5824-5829.

Highly efficient sequential N,N,C-trialkylation of α-N-acyloxyimino esters, Isao Mizota, Tatsuya Maeda, Makoto Shimizu, Tetrahedron 2015, 71, 5793-5799.

Synthesis of Multisubstituted Dihydroquinoxaline Derivatives by Tandem N-Alkylation and Addition Reactions of 3-Oxoquinoxaline-2-carboxylates, Satoru Miyamaru, Kazuto Umezu, Akinori Ito, and Makoto Shimizu, Eur. J. Org. Chem. 2015, 3327-3337.

Nucleophilic Addition Reaction to the Iminium Salts Generated from Pipecolic Acid Derivatives and Application to the Synthesis of Bicyclic Compounds, Makoto Shimizu, Atsuhiro Yato and Takato Kawamura, Asian J. Org. Chem., 2015, 4, 128-131.

2-Aryl-4-quinolone Synthesis Using the Thermal Rearrangement of Iminocyclobutenones,Iwao Hachiya, Keiichi Yokoyama, Akinori Ito, and Makoto Shimizu,Heterocycles, 2015, 90, (1), 97-103.

N-Alkylation of α-Iminophosphonates and application to Horner-Wadsworth-Emmons Reaction, Makoto Shimizu, Masasato Tateishi, and Isao Mizota, Chem. Lett., 2014, 43, (11), 1752-1754.

Chiral β-Lactam Synthesis through the Enantioselective Reduction of Iminocyclobutenones and Thermal Rearrangement of Aminocyclobutenones, Iwao Hachiya, Akinori Ito, and Makoto Shimizu, Asian J. Org. Chem., 2014, 3, (5), 614-618.

Titanium Tetraiodide-Mediated Organic Reactions, Tsuyoshi Haneishi, Iwao Hachiya, and Makoto Shimizu, Arabian J. Sci. Eng., 2014, 39,(9), 6599-6616.

Integrated reactions based on the sequential addition to α-imino esters, Kaichiro Koyama, Isao Mizota, and Makoto Shimizu, Pure Appl. Chem., 2014, 86, (5), 755-764.

Chemoselective reductions and iodinations using titanium tetraiodide, Iwao Hachiya and Makoto Shimizu,Tetrahedron Lett., 2014, 55, (17), 2781-2788.

Tandem N-Alkylation/Vinylogous Aldol Reaction of β,γ-Alkenyl α-Iminoester, Hirotaka Tanaka, Isao Mizota, and Makoto Shimizu, Org. Lett., 2014, 16, (8) 2276-2279.

Two-Step Synthesis of 3,4-Ethylenedioxythiophene (EDOT) from 2,3-Butanedione, Iwao Hachiya, Toshihiro Yamamoto, Tatsuhiko Inagaki, Tomohiro Matsumoto, Atsushi Takahashi, Isao Mizota, and Makoto Shimizu, Heterocycles, 2014, 88, (1), 607-612.

Diastereoselective Iodo Aldol Reaction of g-Alkoxy a,b-Alkynyl Ketone Derivatives Promoted by Titnium Tetraiodide,Iwao Hachiya, Shingo Ito, Shota Kayaki, and Makoto Shimizu, Asian J. Org. Chem., 2013, 2, (11), 931-934.

Regioselective Tandem N-Alkylation/C-Acylation of β,γ-Alkynyl α-Imino Esters, Isao Mizota, Yuri Matsuda, Satoshi Kamimura, Hirotaka Tanaka, and Makoto Shimizu, Org. Lett., 2013, 15, (16), 4206-4209.

Synthesis of Azulene Derivatives Having an Azathiacrown Ether Moiety and Their Selective Color Reaction toward Silver Ion, Shigeharu Wakabayashi, Miyuki Uchida, Rika Tanaka, and Makoto Shimizu, Asian J. Org. Chem., 2013, 2, (9), 786-791.

Tandem N-Alkylation-Addition Reaction of α-Imino Esters and Application to a New Flow System, Takanori Sano, Isao Mizota, and Makoto Shimizu, Chem. Lett., 2013, 42, (9) 995-997.

Highly Diastereoselective Tandem N-Alkylation-Mannich Reaction of α-Imino Esters, M. Shimizu, D. Kurita, and I. Mizota, Asian J. Org. Chem., 2013, 2, (3) 208-211.

A new single-ion polymer electrolyte based on polyvinyl alcohol for lithium ion batteries, Y. S. Zhu, X. J. Wang, Y. Y. Hou, X. W. Gao, L. L. Liu, Y. P. Wu, and M. Shimizu, Electrochimica Acta, 2013, 87, (1) 113–118.

Synthesis of Indolin-3-ones and Tetrahydro-4-quinolones Using α-Imino Esters, M. Shimizu, Y. Takao, H. Katsurayama, and I. Mizota, Asian J. Org. Chem., 2013, 2, (2) 130-134.

Synthesis of a-Amino Ketones and O-Alkyloximes by Titanium Tetrahalide Promoted Ring-opening Reaction of 2-Mono-substitued Azetidine-3-ones and Their O-Alkyloximes, S. Ariga, S. Hata, D. Fukuda, T. Nishi, I. Hachiya, and M. Shimizu, Heterocycles, 2012, 86, (2), 1187-1210.

Synthesis of a-Dialkylamino Esters Using Tandem N,N-Dialkylation of a-Sulfoximino Ester, S. Hata, T. Maeda, and M. Shimizu, Bull. Chem. Soc. Jpn., 2012, 85, (11) 1203-1205.

Sulfur-Containing Pyridylazulenes: Synthesis and Chromogenic Behaviors for Heavy Metal Ions, S. Wakabayashi, E. Matsumoto, M. Nishiguchi, R. Yamaoka, M. Ishiura, M. Tsuji, and M. Shimizu, Heterocycles, 2012, 85, (9), 2251-2258.

Integrated Reactions Using Addition to Conjugated Imines and Iminium Salts, Takafumi Nishi, Isao Mizota, and Makoto Shimizu, Pure Appl. Chem., 2012, 84, (12) 2609-2617.

Synthesis of Nitrogen-containing Heterocycles Using Conjugate Addition Reactions of Nucleophiles to a,b-Unsaturated Imines, Iwao Hachiya, Isao Mizota, and Makoto Shimizu, Heterocycles, 2012, 85, (5), 993-1016.

Synthesis of γ,δ-Unsaturated Quaternary α-Alkylamino Acids Using Umpolung Reaction and Claisen Rearrangement, Isao Mizota, Katsuki Tanaka, and Makoto Shimizu, Tetrahedron Lett., 2012, 53, (14), 1847-1850.

Regioselctive Ring-opening Reaction of 2-Mono-substituted Azetidin-3-ones Promoted by the Combines Use of Titanium Tetraiodide and Its Chloro or Bromo Counterpart, Shingo Hata, Daisuke Fukuda, Iwao Hachiya, and Makoto Shimizu, Heterocycles, 2012, 84, (1), 301-307.

Synthesis of a,a-Disubstituted a-Amino Esters: Nucleophilic Addition to Iminium Salts Generated from Amino Ketene Silyl Acetals, Shingo Hata, Hiroshi Koyama, and Makoto Shimizu, J. Org. Chem., 2011, 76, (23), 9670-9677.

Reductive Aminopropylation of Ketene Silyl (Thio)acetals Leading to the Synthesis of δ-Amino Esters, Isao Mizota, Shun Agatani, Iwao Hachiya, Makoto Shimizu, Tetrahedron Lett., 2011, 52, (41) 5388-5391.

Double Nucleophilic Addition Reaction to Acrolein with Ketene Silyl Acetals and Allylborolanes Catalyzed by Proline, Makoto Shimizu, Mami Kawanishi, Akinori Itoh, Isao Mizota, and Iwao Hachiya, Chem. Lett., 2011, 40, (8) 862-863.

Research Progress of Gel Polymer Electrolytes for Lithium Ion Batteries, Peng Zhang, Linlin Li, Dannong He, Yuping Wu, and Makoto Shimizu, Acta Polymerica Sinica, 2011, (2) 125-131.

Titanium Tetraiodide Promoted Reductive Enolate Formation of a- Tosyloxy Ketone Derivatives and Aldol Reaction with Aldehydes, Iwao Hachiya, Takao Inagaki, Yasuhisa Ishihara, and Makoto Shimizu, Bull. Chem. Soc. Jpn., 2011, 84, (4) 419-421.

Efficient Mannich Reaction Using Iminium Salts Generated from Glycine Derivatives, Makoto Shimizu, Toshiki Kusunoki, Mari Yoshida, Koichi Kondo, and Isao Mizota, Chem. Lett., 2011, 40, (4) 351-353.

Titanium Tetraiodide Promoted Tandem Prins Reaction of Alkynes with Acetals: Synthesis of (Z,Z)-1,5-Diiodo-1,3,5-triarylpenta-1,4-dienes, Makoto Shimizu, Kanako Okura, Takuya Arai, and Iwao Hachiya, Chem. Lett., 2010, 39, (10) 1052-1054.

Use of N-Allylidene-1,1-diphenylethanamine as a Latent Acrolein Synthon in the Double Nucleophilic Addition Reaction of Ketene Silyl (Thio)acetals and Allylborolanes Makoto Shimizu, Mami Kawanishi, Isao Mizota, and Iwao Hachiya, Org. Lett., 2010, 12, (16), 3571-3573.

Synthesis of 3,4-Ethylenedioxythiophene (EDOT) from (Z)-But-2-ene-1,4-diol or But-2-yne-1,4-diol, Iwao Hachiya, Tomohiro Matsumoto, Tatsuhiko Inagaki, Atsushi Takahashi, and Makoto Shimizu, Heterocycles, 2010, 82, (1), 449-460.

A New Method for the Synthesis of Multi-substituted Pyrroles of Biological Interest by Double Nucleophilic Addition to a,b-Unsaturated Imines, Atsushi Takahashi, Shiho Kawai, Iwao Hachiya, and Makoto Shimizu, Eur. J. Org. Chem., 2010, (1) 191-200.

Reductive Aldol and Mannich-Type Reactions of Azetidin-3-ones Promoted by Titanium Tetraiodide, Shingo Hata, Daisuke Fukuda, Iwao Hachiya, and Makoto Shimizu, Chem. Asian J., 2010, 5, (1), 473-477.

Facile Synthesis and Ring-Opening of 4-(Tributylstannyl)pyrrolidine-2-carboxylates, Makoto Shimizu, Hiromi Ando, Hitoshi Shibuya, and Iwao Hachiya, Heterocycles, 2010, 80, (2), 773-778.

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