Mizota Group Publications (chronological order)

63. Front cover: Synthesis of 2H-1,4-Oxazin-3(4H)-one Utilizing Umpolung Reaction to α-Hydrazonoketone (Asian J. Org. Chem. 3/2025)
    Isao Mizota, Keiji Oshima, Nozomi Hoshiai, Ayaki Yamamoto, Masaki Mitani, Rabbia Batool, Bo-Tau Liu, Makoto Shimizu [doi:10.1002/ajoc.202580301]
62. Synthesis of 2H-1,4-Oxazin-3(4H)-one Utilizing Umpolung Reaction to α-Hydrazonoketone
    Isao Mizota, Keiji Oshima, Nozomi Hoshiai, Ayaki Yamamoto, Masaki Mitani, Rabbia Batool, Bo-Tau Liu, Makoto Shimizu
    Asian J. Org. Chem. 2025, 14, e20240638.
61. Innovations in Silicone Hydrogels: Achieving High Oxygen Permeability with Maintained Equilibrium Water Content
    Bo-Tau Liu, You-Kai Chang, Rong-Ho Lee, Isao Mizota, Kai-Ting Sun, Yi-Ting Lu
    Adv. Eng. Mater. 2024, 26, 240867.
60. Development of a New Branched Dicarboxylic Acid for High-Performance Aluminum Electrolytic Capacitors
    Isao Mizota
    Advanced Devices and Materials Trend Report, 2024,4, 7-16.
59. Umpolung Reaction of Imine Analogues and Their Development into Biologically Active Compounds
    Isao Mizota, Makoto Shimizu
    J. Synth. Org. Chem. Jpn. 2024, 82, 670-683.
58. Critical Review of Photocatalytic Reactor Designs for Environmental Applications
    S. K. Sheik Moideen Thaha, Pugazhenthiran Nalandhiran, Selvam Kaliyamoorthy, Isao Mizota, Ramalinga V. Mangalaraja, Panneerselvam Sathishkumar
    Photocatalysis for Energy and Environmental Applications: Current Trends and Future Perspectives (Green Energy and Technology Series), P. Sathishkumar, Ed; Springer, 2024, Chapter 1, 1-50.
57. Synthesis of Dicarboxylic Acids Comprising an Ether Linkage and Cyclic Skeleton and Its Further Application for High-performance Aluminum Electrolyte Capacitors
    Isao Mizota, Toshihiro Yamamoto, Selvam Kaliyamoorthy, Makoto Shimizu, Balamurugan Rathinam, Bo-Tau Liu, Noburo Kuroki, Junichi Kiyosawa, Hiroyuki Tanaka
    ACS Omega 2024, 9, 10628-10639.
56. Hydrophilic Ligand Exchange Induces Improved Upconversion Nanoparticle Incorporation in Dye-Sensitized Solar Cells with Efficiency Exceeding 8% in a Low-Temperature Fabrication Process
    Bo-Tau Liu, Jin-Ci Syu, Isao Mizota, Balamurugan Rathinam, I.-Ru Chen, Yi-Ting Lu
    ACS Appl. Energy Mater. 2024, 7, 965-973.
55. Highly Stereoselective Synthesis of γ,δ-Unsaturated Quaternary α-Amino Esters via the Tandem N-Alkylation/Claisen Rearrangement of α-Imino Allylesters
    Isao Mizota, Toshikazu Fukaya, Yumi Miwa, Yoshinari Kobayashi, Tomoki Ejima, Mizuki Yamaguchi, Makoto Shimizu
    Asian J. Org. Chem. 2023, 12, e202300063.
54. Highly Selective Synthesis of α-Aminoamide Utilizing an Umpolung Reaction and Characteristics of α-Hydrazonoester
    Isao Mizota, Yusuke Nakamura, Shunsuke Mizutani, Nanami Mizukoshi, Shunya Terasawa, Makoto Shimizu
    Org. Lett. 2021, 23, 4168-4172.
53. N-Alkylation/aldol reaction of α-aldimino thioesters: a facile three-component coupling reaction
    Makoto Shimizu, Asako Higashino, Isao Mizota, Yusong Zhu
    RSC Adv. 2021, 11, 13097-13104.
52. Regulate Phosphorus Configuration in High P-Doped Hard Carbon as a Superanode for Sodium Storage
    Xiaoyan Wang, Mingxing Hou, Zhenglu Shi, Xiang Liu, Isao Mizota, Hongtao Lou, Bin Wang, Xianhua Hou
    ACS Appl. Mater. Interfaces 2021, 13, 12059-12068.
51. 2,3-Dimethoxy-2,3-dimethyl-1,4-dioxane as a useful precursor to 2,3-dimethylene-1,4-dioxane for [4+2] cycloaddition reaction
    Makoto Shimizu, Toshihiro Yamamoto, Hiroaki Shindo, Isao Mizota, Yusong Zhu
    RSC Adv. 2021, 11, 7972-7980.
50. Preparation of α-Perfluoroalkyl Ketones from α,β-Unsaturated Ketones via Formal Hydroperfluoroalkylation
    Kalipada Jana, Isao Mizota, Armido Studer
    Org. Lett. 2021, 23, 1280-1284.
49. Considering Critical Factors of Silicon/Graphite Anode Materials for Practical High-Energy Lithium-Ion Battery Applications
    Shenggong He, Shimin Huang, Shaofeng Wang, Isao Mizota, Xiang Liu, Xianhua Hou
    Energy Fuels 2020, 35, 944-964.
48. An efficient method for 3,4-dihydroisoquinolinium ion formation, leading to a facile introduction of nucleophiles
    Makoto Shimizu, Takato Kawamura, Shinya Fukumoto, Isao Mizota, Yusong Zhu
    J. Heterocycl. Chem. 2020, 58, 751-756.
47. Umpolung Reaction of α-Tosyloximino Ester Using a Flow System
    Kazuki Ota, Shinya Fukumoto, Taiki Iwase, Isao Mizota, Makoto Shimizu, Iwao Hachiya
    Synlett 2020, 31, 1930-1936.
46. Syntheses of Nitrogen Containing Compounds Utilizing Umpolung Reaction to Iminoester
    Isao Mizota
    Chemistry and Chemical Industry 2020, 73-10, 746-747.
45. Industry-academia Collaboration Aiming to Develop the Aluminum Electrolytic Capacitors of High Performance
    Isao Mizota, Iwao Hachiya, Keisuke Kato, Naoya Torikai, Yorozu Yokomori
    Bulltein of the Tokai Chemical Industry Society 2020, 280, 10-14.
44. Preparation and facile addition reactions of iminium salts derived from amino ketene silyl acetal and amino silyl enol ether
    Makoto Shimizu, Shingo Hata, Koichi Kondo, Kazuhiro Murakami, Isao Mizota, Yusong Zhu
    RSC Adv. 2020, 10, 27874-27883.
43. Electrophilic Amination Reactions with 1H-Indazole-3-carboxylates: Synthesis of Amino Acid Frameworks and 3-Amino-2-oxindoles
    Isao Mizota, Mayuko Mori, Makoto Shimizu
    J. Heterocycl. Chem. 2020, 57, 3002-3010.
42. Synthesis of Tetramic Acid Derivatives via Tandem Umpolung Alkyation/reduction/cyclization Reaction of γ-Hydrazono β-Ketoester
    Isao Mizota, Miki Maeda, Kiho Imoto, Makoto Shimizu
    Org. Lett. 2020, 22, 3079-3083.
41. An Umpolung Reaction of α-Iminothioesters possessing a Cyclopropyl Group
    Makoto Shimizu, Takayoshi Morimoto, Yusuke Yanagi, Isao Mizota, Yusong Zhu
    RSC Adv. 2020, 10, 9955-9963.
40. An Umpolung Reaction of α-Iminonitriles and its Application to the Synthesis of Aminomalononitriles
    Makoto Shimizu, Yuki Furukawa, Isao Mizota, Yusong Zhu
    New J. Chem. 2020, 44, 152-161.
39. Double Nucleophilic Addition to Iminomalonate, Leading to the Synthesis of Quaternary α-Amino Diesters and Desymmetrization of the Products
    Makoto Shimizu, Miki Mushika, Isao Mizota, Yusong Zhu
    RSC Adv. 2019, 9, 23400-23407.
38. A Facile Synthesis of 2-Methyl-3-oxoindoline-2-carboxylates Utilizing Aza-Brook Rearrangement as a Crucial Step
    Makoto Shimizu, Haruna Katsurayama, Isao Mizota, Yusong Zhu
    J. Heterocycl. Chem. 2019, 56, 2479-2486.
37. A Facile Approach to 2-Alkoxyindoline-3-one and Its Application to the Synthesis of N-Benzyl Matemone
    Makoto Shimizu, Hayao Imazato, Isao Mizota, Yusong Zhu
    RSC Adv. 2019, 9, 17341-17346.
36. Tandem N,N-Dialkylation Reaction to Synthesize α-AminoAcid Derivatives
    Selected by the Editorial Board of Synfacts (Synfacts 2019, 1077.)
    Tandem N,N-Dialkylation Reaction of N-Trimethylsilyl α-Iminoesters Utilizing an Umpolung Reaction and Characteristics of the Silyl Substituent: Synthesis of Pyrrolidine, Piperidine, and Iminodiacetate
    Isao Mizota, Yurie Tadano, Yusuke Nakamura, Tomoki Hramiishi, Miyuki Hotta, Makoto Shimizu
    Org. Lett. 2019, 21, 2663-2667.
35. Tandem N,N-Dialkylation Reaction of N-Trimethylsilyl α-Iminoesters Utilizing an Umpolung Reaction and Characteristics of the Silyl Substituent: Synthesis of Pyrrolidine, Piperidine, and Iminodiacetate
    Isao Mizota, Yurie Tadano, Yusuke Nakamura, Tomoki Hramiishi, Miyuki Hotta, Makoto Shimizu
    Org. Lett. 2019, 21, 2663-2667.
34. Efficient One-pot Syntheses of 3-Amino-2-pyrones and 3-Amino-5,6-dihydro-2-pyridones from β,γ-Unsaturated α-Iminoesters: Application to the Synthesis of A Tricyclic Pyranoindole
    Kenta Nakahama, Misato Suzuki, Mami Ozako, Isao Mizota, Makoto Shimizu
    Asian J. Org. Chem. 2018, 7, 910-913.
33. Umpolung Reaction of α-Imino Thioesters and the Subsequent C-C Bond Formation with the Unexpected Alkylthio Rearrangement
    Isao Mizota, Chihiro Ueda, Yun Tesong, Yusuke Tsujimoto, Makoto Shimizu
    Org. Lett. 2018, 20, 2291-2296.
32. New Synthetic Reactions Using the Iodotitanation Ability of Titanium Tetraiodide
    Iwao Hachiya, Isao Mizota, Makoto Shimizu
    J. Synth. Org. Chem. Jpn. 2017, 75, 1226-1237.
31. Synthesis of 1,2-Diamino Acid Derivatives Utilizing Diastereoselective Tandem N-Alkylation/Homo- and Cross-addition Reaction of α-Aldimino Thioesters
    Isao Mizota, Yuji Nakajima, Asako Higashino, Makoto Shimizu
    Arab. J. Sci. Eng. 2017, 42, 4249-4261.
30. Synthesis of δ-Lactone and Amino Acid Frameworks Utilizing the Umpoled Reactivity of β,γ-Alkenyl α-Iminoester
    Mami Kawanishi, Isao Mizota, Kana Aratake, Hirotaka Tanaka, Kenta Nakahama, Makoto Shimizu
    Bull. Chem. Soc. Jpn. 2017, 90, 395-403.
29. SYNTHESIS OF MULTI-SUBSTITUTED 1,4-BENZOXAZINE USING AN UMPOLUNG REACTION WITH 2-OXO-1,4-BENZOXAZINE-3-CARBOXYLATES
    Takanori Tanaka, Isao Mizota, Makoto Shimizu
    Heterocycles 2017, 95, 830-843.
28. Titanium tetraiodide-mediated diastereoselective iodo-aldol and Mannich reactions of γ-alkoxy-α,β-alkynyl ketone derivatives
    Kai Yashiro, Shingo Ito, Shota Kayaki, Keito Sakata, Isao Mizota, Iwao Hachiya, Makoto Shimizu
    Tetrahedron 2016, 72, 6875-6885.
27. Exploration into a New Dicarboxylic Acid Derived from Ricinoleic Acid for the Aluminum Electrolytic Capacitors of High Performance
    Isao Mizota, Satoshi Umeshima, Sei Matsunaga, Rinpei Isomura, Kenta Nakahama, Makoto Shimizu, Yorozu Yokomori, Tokihiro Umemura, Noburo Kuroki, Junichi Kiyosawa, Hiroyuki Tanaka
    Bull. Chem. Soc. Jpn. 2016, 89, 1368-1374.
26. FORMAL TOTAL SYNTHESIS OF ARTOCARPIN
    Isao Mizota, Kana Taniguchi, Makoto Shimizu
    Heterocycles 2016, 93, 310-322.
25. Umpolung Reactions of α-Imino Esters: Useful Methods for the Preparation of α-Amino Acid Frameworks
    Isao Mizota, Makoto Shimizu
    Chem. Rec. 2016, 16, 688-702.
24. Highly efficient sequential electrophilic N,N,C-trialkylation of α-N-acyloxyimino esters
    Isao Mizota
    Toyota Kenkyu Hokoku 2015, 68, 159-160.
23. Exploration into a new dicarboxylic acid possessing a carbocyclic structure for the aluminum electrolytic capacitors of high performance
    Isao Mizota
    Chemical Industry 2015, 66, 183-188.
22. Highly efficient sequential N,N,C-trialkylation of α-N-acyloxyimino esters
    Isao Mizota, Tatsuya Maeda, Makoto Shimizu
    Tetrahedron 2015, 71, 5793-5799.
21. N-Alkylation of α-Iminophosphonates and Application to Horner-Wadsworth-Emmons Reaction
    Makoto Shimizu, Masasato Tateishi, Isao Mizota
    Chem. Lett. 2014, 43, 1752-1754.
20. Integrated reactions based on the sequential addition to α-imino esters
    Kaichiro Koyama, Isao Mizota, Makoto Shimizu
    Pure Appl. Chem. 2014, 86, 755-764.
19. Tandem N-Alkylation/Vinylogous Aldol Reaction of β,γ-Alkenyl α-Iminoester
    Hirotaka Tanaka, Isao Mizota, Makoto Shimizu
    Org. Lett. 2014, 16, 2276-2279.
18. TWO-STEP SYNTHESIS OF 3,4-ETHYLENEDIOYTHIOPHENE (EDOT) FROM 2,3-BUTANEDIONE
    Iwao Hachiya, Toshihiro Yamamoto, Tatsuhiko Inagaki, Tomohiro Matsumoto, Atsushi Takahashi, Isao Mizota, Makoto Shimizu
    Heterocycles 2014, 88, 607-612.
17. Regioselective Tandem N-Alkylation/C-Acylation of β,γ-Alkynyl α-Imino Esters
    Isao Mizota, Yuri Matsuda, Satoshi Kamimura, Hirotaka Tanaka, Makoto Shimizu
    Org. Lett. 2013, 15, 4206-4209.
16. Tandem N-Alkylation-Addition Reaction of α-Aldimino Ester and Application to a New Flow System
    Takanori Sano, Isao Mizota, Makoto Shimizu
    Chem. Lett. 2013, 42, 995-997.
15. Highly Diastereoselective Tandem N-Alkylation-Mannich Reaction of α-Imino Esters
    Makoto Shimizu, Daiji Kurita, Isao Mizota
    Asian J. Org. Chem. 2013, 2, 208-211.
14. Synthesis of Indolin-3-ones and Tetrahydro-4-quinolones from α-Imino Esters
    Makoto Shimizu, Yuki Takao, Haruna Katsurayama, Isao Mizota
    Asian J. Org. Chem. 2013, 2, 130-134.
13. Integrated reactions using addition to conjugated imines and iminium salts
    Takafumi Nishi, Isao Mizota, Makoto Shimizu
    Pure Appl. Chem. 2012, 84, 2609-2617.
12. SYNTHESIS OF NITROGEN-CONTAINING HETEROCYCLES USING CONJUGATE ADDITION REACTIONS OF NUCLEOPHILES TO α,β-UNSATURATED IMINES
    Iwao Hachiya, Isao Mizota, Makoto Shimizu
    Heterocycles 2012, 993-1016.
11. Synthesis of γ,δ-unsaturated quaternary α-alkylamino acids using umpolung reaction and Claisen rearrangement
    Isao Mizota, Katsuki Tanaka, Makoto Shimizu
    Tetrahedron Lett. 2012, 53, 1847-1850.
10. Transformation of the Organic Molecules with Titanium Iodide
    Makoto Shimizu, Takafumi Nishi, Isao Mizota, Iwao Hachiya
    Bulltein of the Tokai Chemical Industry Society, 2012, 272, 4-9.
9. >Reductive aminopropylation of ketene silyl (thio)acetals leading to the synthesis of δ-amino esters
   Isao Mizota, Shun Agatani, Iwao Hachiya, Makoto Shimizu
   Tetrahedron Lett. 2011, 52, 5388-5391.
8. Double Nucleophilic Addition to Acrolein with Ketene Silyl Acetals and Allylborolanes Catalyzed by Proline
   Makoto Shimizu, Mami Kawanishi, Akinori Itoh, Isao Mizota, Iwao Hachiya
   Chem. Lett. 2011, 40, 862-863.
7. Efficient Mannich Reaction Using Iminium Salts Generated from Glycine Derivatives
   Makoto Shimizu, Toshiki Kusunoki, Mari Yoshida, Koichi Kondo, Isao Mizota
   Chem. Lett. 2011, 40, 351-353.
6. N-Allylidene-1,1-diphenylethanamine as Acrolein Synthon
   Selected by the Editorial Board of Synfacts (Synfacts 2010, 1292.)
   Use of N-Allylidene-1,1-diphenylethanamine as Acrolein Synthon in the Double Nucleophilic Addition Reaction of Ketene Silyl (Thio)acetals and Allylborolanes
   Makoto Shimizu, Mami Kawanishi, Isao Mizota, Iwao Hachiya
   Org. Lett. 2010, 12, 3571-3573.
5. Use of N-Allylidene-1,1-diphenylethanamine as a Latent Acrolein Synthon in the Double Nucleophilic Addition Reaction of Ketene Silyl (Thio)acetals and Allylborolanes
   Makoto Shimizu, Mami Kawanishi, Isao Mizota, Iwao Hachiya
   Org. Lett. 2010, 12, 3571-3573.
4. Reductive Self-coupling Reaction of Imines and Aldehydes Induced by Strontium Metal
   Norikazu Miyoshi, Tadashi Kohno, Makoto Wada, Sei Matsunaga, Isao Mizota, Makoto Shimizu
   Chem. Lett. 2009, 38, 984-985.
3. N-Allylideneamines Derived from Acrolein: Synthesis and Use as Acceptors of Two Nucleophiles
   Isao Mizota, Yuri Matsuda, Iwao Hachiya, Makoto Shimizu
   Eur. J. Org. Chem. 2009, 4073-4084.
2. Conjugated imines and iminium salts as versatile acceptors of nucleophiles
   Makoto Shimizu, Iwao Hachiya, Isao Mizota
   Chem. Commun. 2009, 874-889.
1. Synthesis of N-Allylideneamines and Their Use for the Double Nucleophilic Addition of Ketene Silyl (Thio)acetals and Trimethylsilyl Cyanide
   Isao Mizota, Yuri Matsuda, Iwao Hachiya, Makoto Shimizu
   Org. Lett. 2008, 10, 3977-3980.

Patents

7. Electrolytic solution for driving electrolytic capacitors
   Makoto Shimizu, Isao Mizota, Yorozu Yokomori, Junichi Kiyosawa, Yoshio Ito, Hiroyuki Tanaka
   Japanese Patent Kokai 2021-086870, 2019.
6. Electrolytic solution for driving electrolytic capacitors
   Makoto Shimizu, Isao Mizota, Yorozu Yokomori, Junichi Kiyosawa, Yoshio Ito, Hiroyuki Tanaka
   Patent JP 6399466, 2017.
5. Electrolytic solution for driving electrolytic capacitors
   Makoto Shimizu, Isao Mizota, Yorozu Yokomori, Junichi Kiyosawa, Hiroyuki Tanaka
   Patent JP 6566305, 2015.
4. Electrolytic solution for driving electrolytic capacitors
   Makoto Shimizu, Isao Mizota, Yorozu Yokomori, Junichi Kiyosawa, Hiroyuki Tanaka
   Patent JP 6459540, 2015.
3. Electrolytic solution for driving electrolytic capacitors
   Makoto Shimizu, Isao Mizota, Yorozu Yokomori, Junichi Kiyosawa, Hiroyuki Tanaka
   Patent JP 6459432, 2014.
2. Electrolytic solution for driving electrolytic capacitors
   Makoto Shimizu, Isao Mizota, Yorozu Yokomori, Junichi Kiyosawa, Yoshio Ito, Hiroyuki Tanaka
   Patent JP 6201172, 2013.
1. Electrolytic solution for driving electrolytic capacitors
   Makoto Shimizu, Isao Mizota, Yorozu Yokomori, Junichi Kiyosawa, Yoshio Ito, Hiroyuki Tanaka
   Patent JP 6131136, 2013.